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Department of
Anesthesiology

Provides services for over 50,000 anesthetics annually in 46 anesthetic sites, primarily at University of Cincinnati Medical Center.

Photo of Steve C. Danzer, PhD

Research Interests

My laboratory examines changes in the structure and function of brain circuitry that drive focal epileptogenesis, with a particular interest in epilepsies driven by gene mutations in the mTOR signaling pathway. The overall goal of our research is to identify common disease-causing mechanisms that are clinically actionable.

Peer Reviewed Publications

Dusing, Mary; LaSarge, Candi L; White, Angela; Jerow, Lilian G; Gross, Christina; Danzer, Steve C 2023. Neurovascular Development in Pten and Tsc2 Mouse Mutants. eNeuro, 10 2,

Kraus, Kimberly L; Nawreen, Nawshaba; Godale, Christin M; Chordia, Arihant P; Packard, Ben; LaSarge, Candi L; Herman, James P; Danzer, Steve C 2023. Hippocampal glucocorticoid receptors modulate status epilepticus severity. Neurobiology of disease, 178 , 106014

LaSarge, Candi L; McCoy, Carlie; Namboodiri, Devi V; Hartings, Jed A; Danzer, Steve C; Batie, Matthew R; Skoch, Jesse 2023. Spatial and Temporal Comparisons of Calcium Channel and Intrinsic Signal Imaging During in Vivo Cortical Spreading Depolarizations in Healthy and Hypoxic Brains. Neurocritical care, 39 3, 655-668

Kraus, Kimberly L; Chordia, Arihant P; Drake, Austin W; Herman, James P; Danzer, Steve C 2022. Hippocampal interneurons are direct targets for circulating glucocorticoids. The Journal of comparative neurology, 530 12, 2100-2112

LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Riccetti, Matthew R; Namboodiri, Devi V; Tiwari, Durgesh; Gross, Christina; Danzer, Steve C 2021. mTOR-driven neural circuit changes initiate an epileptogenic cascade. Progress in neurobiology, 200 , 101974

Arafa, Salwa R; LaSarge, Candi L; Pun, Raymund Y K; Khademi, Shadi; Danzer, Steve C 2019. Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth. Experimental neurology, 311 , 125-134

LaSarge, Candi L; Pun, Raymund Y K; Gu, Zhiqing; Santos, Victor R; Danzer, Steve C 2019. Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? Experimental neurology, 321 , 113029

Ngwenya, Laura B; Danzer, Steve C 2018. Impact of Traumatic Brain Injury on Neurogenesis. Frontiers in neuroscience, 12 , 1014

Hosford, Bethany E; Rowley, Shane; Liska, John P; Danzer, Steve C 2017. Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression. Scientific reports, 7 1, 18015

Rowley, Shane; Sun, Xiaofei; Lima, Isabel V; Tavenier, Alexandra; de Oliveira, Antonio Carlos Pinheiro; Dey, Sudhansu K; Danzer, Steve C 2017. Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. Epilepsia, 58 12, e162-e166

Santos, Victor R; Pun, Raymund Y K; Arafa, Salwa R; LaSarge, Candi L; Rowley, Shane; Khademi, Shadi; Bouley, Tom; Holland, Katherine D; Garcia-Cairasco, Norberto; Danzer, Steve C 2017. PTEN deletion increases hippocampal granule cell excitability in male and female mice. Neurobiology of disease, 108 , 339-351

Hosford, Bethany E; Liska, John P; Danzer, Steve C 2016. Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 43, 11013-11023

LaSarge, Candi L; Pun, Raymund Y K; Muntifering, Michael B; Danzer, Steve C 2016. Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells. Neurobiology of disease, 96 , 105-114

LaSarge, Candi L; Santos, Victor R; Danzer, Steve C 2015. PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure. Neurobiology of disease, 75 , 142-50

Hester, Michael S; Danzer, Steve C 2013. Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 21, 8926-36

Hofacer, Rylon D; Deng, Meng; Ward, Christopher G; Joseph, Bernadin; Hughes, Elizabeth A; Jiang, Connie; Danzer, Steve C; Loepke, Andreas W 2013. Cell age-specific vulnerability of neurons to anesthetic toxicity. Annals of neurology, 73 6, 695-704

Pun, Raymund Y K; Rolle, Isaiah J; Lasarge, Candi L; Hosford, Bethany E; Rosen, Jules M; Uhl, Juli D; Schmeltzer, Sarah N; Faulkner, Christian; Bronson, Stefanie L; Murphy, Brian L; Richards, David A; Holland, Katherine D; Danzer, Steve C 2012. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron, 75 6, 1022-34

Murphy, Brian L; Danzer, Steve C 2011. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 8, 2959-64

Murphy, Brian L; Pun, Raymund Y K; Yin, Hulian; Faulkner, Christian R; Loepke, Andreas W; Danzer, Steve C 2011. Heterogeneous integration of adult-generated granule cells into the epileptic brain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 1, 105-17

Walter, Cynthia; Murphy, Brian L; Pun, Raymund Y K; Spieles-Engemann, Anne L; Danzer, Steve C 2007. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 28, 7541-52

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