- Ph.D.: University of Waterloo (Structural Enzymology - Holyoak Lab)
- M.Sc.: University of Waterloo (Structural Enzymology - Holyoak Lab)
- B.Sc.: University of Waterloo (Honours Biomedical Sciences & Minor in Human Nutrition & Minor in Biology )
- Old Chemistry Building 711
- Office 513-556-8165
- Email mcleodmw@ucmail.uc.edu
Indergaard, John A; Mahmood, Kashfia; Gabriel, Leo; Zhong, Gary; Lastovka, Adam; McLeod, Matthew J; Thorne, Robert E 2025. Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution. IUCrJ, 12 Pt 3, 372-383
McLeod, Matthew J; Barwell, Sarah A E; Holyoak, Todd; Thorne, Robert E 2025. A structural perspective on the temperature dependent activity of enzymes. Structure, 33 5, 924-934.e2
Abdelhady, Abdallah W; Mittan-Moreau, David W; Crane, Patrick L; McLeod, Matthew J; Cheong, Soon Hon; Thorne, Robert E 2024. Ice formation and its elimination in cryopreservation of oocytes. Scientific reports, 14 1, 18809
Lee, Eunjeong; McLeod, Matthew J; Redzic, Jasmina S; Marcolin, Barbara; Thorne, Robert E; Agarwal, Pratul; Eisenmesser, Elan Zohar 2023. Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle. Frontiers in molecular biosciences, 10 , 1244587
McLeod, Matthew J; Holyoak, Todd 2023. Biochemical, structural, and kinetic characterization of PPi -dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii. Proteins, 91 9, 1261-1275
McLeod, Matthew J; Tran, Norman; McCluskey, Gregory D; Gillis, Tom D; Bearne, Stephen L; Holyoak, Todd 2023. A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate. Protein science : a publication of the Protein Society, 32 6, e4648
Tran, Norman; Dasari, Sathish; Barwell, Sarah A E; McLeod, Matthew J; Kalyaanamoorthy, Subha; Holyoak, Todd; Ganesan, Aravindhan 2023. The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease. Nature communications, 14 1, 5625
Clinger, Jonathan A; Moreau, David W; McLeod, Matthew J; Holyoak, Todd; Thorne, Robert E 2021. Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection. IUCrJ, 8 Pt 5, 784-792
Mcleod, Matthew J; Krismanich, Anthony P; Assoud, Abdeljalil; Dmitrienko, Gary I; Holyoak, Todd 2019. Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase. Biochemistry, 58 37, 3918-3926
Cui, Danica S; Broom, Aron; Mcleod, Matthew J; Meiering, Elizabeth M; Holyoak, Todd 2017. Asymmetric Anchoring Is Required for Efficient Ω-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56 15, 2106-2115
Johnson, Troy A; Mcleod, Matthew J; Holyoak, Todd 2016. Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55 3, 575-87
Balan, Marc D; Mcleod, Matthew J; Lotosky, William R; Ghaly, Mark; Holyoak, Todd 2015. Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54 38, 5878-87