Jonathan Van Vranken

Contact Information

Email vanvrajn@ucmail.uc.edu

Peer Reviewed Publications

Chakrabarty, Ram P; Van Vranken, Jonathan G; Aoi, Yuki; Poor, Taylor A; McElroy, Gregory S; Vasan, Karthik; Soliman, Shimaa H A; Iwanaszko, Marta; Grant, Rogan A; Howard, Benjamin C; Reczek, Colleen R; Chandel, Anjali D; Kahl, Michael; Xu, Zhaofa; Helmin, Kathryn A; Jin, Qiushi; Wang, Dongmei; Gao, Peng; Blum, Jenna L E; Sebo, Zachary L; Yue, Feng; Ma, Yongchao C; Davidson, Shawn M; Gygi, Steven P; Weinberg, Samuel E; Singer, Benjamin D; Han, SeungHye; Shilatifard, Ali; Chandel, Navdeep S 2026. Mitochondrial L-2-hydroxyglutarate is a physiological signalling metabolite. Nature, ,

Cho, Juyeong; Danner, Rebecca; Kim, Woo Sung; Williams, Jonathan; Singh, Anshit; Han, Jiyoung A; Van Vranken, Jonathan G; Walker, Allison S; Rhoads, Timothy; Chaudhari, Snehal N 2026. Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation. bioRxiv : the preprint server for biology, ,

Nicholson, Rebekah J; Cedeño-Rosario, Luis; Maschek, J Alan; Lonergan, Trevor; Van Vranken, Jonathan G; Kruse, Angela R S; Stubben, Chris J; Wang, Liping; Stuart, Deborah; Alcantara, Queren A; Revelo, Monica P; Rutter, Kate; Pahulu, Mayette; Taloa, Jacob; Wu, Xuanchen; Kim, Juwan; Kim, Juna; Hall, Isaac; Clark, Amanda J; Parikh, Samir; Spraggins, Jeffrey; Romero, Donna; Blitzer, Jeremy T; Gygi, Steven P; Rutter, Jared; Holland, William L; Ramkumar, Nirupama; Summers, Scott A 2026. Therapeutic remodeling of the ceramide backbone prevents kidney injury. Cell metabolism, 38 1, 135-156.e10

Cunningham, Corey N; Van Vranken, Jonathan G; Larios, Jakeline; Heyden, Katarina; Gygi, Steven P; Rutter, Jared 2025. A dual-purification system to isolate mitochondrial subpopulations. Journal of cell science, 138 9,

Dumesic, Phillip A; Wilensky, Sarah E; Bose, Symanthika; Van Vranken, Jonathan G; Gygi, Steven P; Spiegelman, Bruce M 2025. RBM43 controls PGC1α translation and a PGC1α-STING signaling axis. Cell metabolism, 37 3, 742-757.e8

Julian, Linda; Crozier, Lisa; Lukow, Devon; Mishra, Sanat; Swamy, Aditi; Hagenson, Ryan A; Sennhenn, Peter; Sausville, Erin L; Mendelson, Brianna; Chuaqui, Claudio; Qiao, Lu; Vasudevan, Anand; Lin, Kuan-Ting; Bhatia, Sonam; Bertomeu, Thierry; Chatr-Aryamontri, Andrew; Zhang, Li; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Nottoli, Timothy; Bai, Suxia; Lakshmipathi, Jayalakshmi; Muthusamy, Viswanathan; Van Vranken, Jonathan G; Gygi, Steven P; Thompson, Sarah L; Smith, Joan C; Anderson, Kendall; Shah, Sanjana; Bindra, Ranjit S; Akerman, Martin; Spector, David L; Krainer, Adrian R; Sheltzer, Jason M 2025. On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions. bioRxiv : the preprint server for biology, ,

Sprenger, Hans-Georg; Mittenbühler, Melanie J; Sun, Yizhi; Van Vranken, Jonathan G; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A; Smythers, Amanda L; Vargas-Castillo, Ariana; Puszynska, Anna M; Spinelli, Jessica B; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L; Gygi, Steven P; Paulo, Joao A; Arthanari, Haribabu; Chouchani, Edward T; Sabatini, David M; Spiegelman, Bruce M 2025. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. Cell metabolism, 37 4, 857-869.e9

Zhao, Ting; He, Lingli; Wong, Lai Ping; Mei, Shenglin; Xia, Jun; Xu, Yanxin; Van Vranken, Jonathan G; Mazzola, Michael; Chen, Lei; Rhee, Catherine; Fang, Tiancheng; Fukushima, Tsuyoshi; Sayles, Leanne C; Diaz, Matthew; Gibbons, J Alex B; Mostoslavsky, Raul; Gygi, Steven P; Dou, Zhixun; Sykes, David B; Sadreyev, Ruslan I; Sweet-Cordero, E Alejandro; Scadden, David T 2025. Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming. Cell metabolism, 37 8, 1667-1681.e13

Ducommun, Serge; Jannig, Paulo R; Cervenka, Igor; Murgia, Marta; Mittenbühler, Melanie J; Chernogubova, Ekaterina; Dias, José M; Jude, Baptiste; Correia, Jorge C; Van Vranken, Jonathan G; Ocana-Santero, Gabriel; Porsmyr-Palmertz, Margareta; McCann Haworth, Sarah; Martínez-Redondo, Vicente; Liu, Zhengye; Carlström, Mattias; Mann, Matthias; Lanner, Johanna T; Teixeira, Ana I; Maegdefessel, Lars; Spiegelman, Bruce M; Ruas, Jorge L 2024. Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition. Molecular metabolism, 82 , 101912

Ouyang, Yeyun; Jeong, Mi-Young; Cunningham, Corey N; Berg, Jordan A; Toshniwal, Ashish G; Hughes, Casey E; Seiler, Kristina; Van Vranken, Jonathan G; Cluntun, Ahmad A; Lam, Geanette; Winter, Jacob M; Akdogan, Emel; Dove, Katja K; Nowinski, Sara M; West, Matthew; Odorizzi, Greg; Gygi, Steven P; Dunn, Cory D; Winge, Dennis R; Rutter, Jared 2024. Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms. eLife, 13 ,

Sprenger, Hans-Georg; Mittenbühler, Melanie J; Sun, Yizhi; Van Vranken, Jonathan G; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A; Vargas-Castillo, Ariana; Puszynska, Anna M; Spinelli, Jessica B; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L; Gygi, Steven P; Arthanari, Haribabu; Chouchani, Edward T; Sabatini, David M; Spiegelman, Bruce M 2024. Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST. bioRxiv : the preprint server for biology, ,

Van Vranken, Jonathan G; Li, Jiaming; Mintseris, Julian; Wei, Ting-Yu; Sniezek, Catherine M; Gadzuk-Shea, Meagan; Gygi, Steven P; Schweppe, Devin K 2024. Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays. eLife, 13 ,

Dumesic, Phillip A; Wilensky, Sarah E; Bose, Symanthika; Van Vranken, Jonathan G; Gygi, Steven P; Spiegelman, Bruce M 2023. RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α. bioRxiv : the preprint server for biology, ,

Mitchell, Dylan C; Kuljanin, Miljan; Li, Jiaming; Van Vranken, Jonathan G; Bulloch, Nathan; Schweppe, Devin K; Huttlin, Edward L; Gygi, Steven P 2023. A proteome-wide atlas of drug mechanism of action. Nature biotechnology, 41 6, 845-857

Mittenbühler, Melanie J; Jedrychowski, Mark P; Van Vranken, Jonathan G; Sprenger, Hans-Georg; Wilensky, Sarah; Dumesic, Phillip A; Sun, Yizhi; Tartaglia, Andrea; Bogoslavski, Dina; A, Mu; Xiao, Haopeng; Blackmore, Katherine A; Reddy, Anita; Gygi, Steven P; Chouchani, Edward T; Spiegelman, Bruce M 2023. Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell metabolism, 35 3, 535-549.e7

Yin, Terry C; Van Vranken, Jonathan G; Srivastava, Dhiraj; Mittal, Ayushi; Buscaglia, Paul; Moore, Autumn E; Verdinez, Jissele A; Graham, Aschleigh E; Walsh, Susan A; Acevedo, Michael A; Kerns, Robert J; Artemyev, Nikolai O; Gygi, Steven P; Sebag, Julien A 2023. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell chemical biology, 30 8, 933-942.e6

Kam, Tae-In; Park, Hyejin; Chou, Shih-Ching; Van Vranken, Jonathan G; Mittenbühler, Melanie J; Kim, Hyeonwoo; A, Mu; Choi, Yu Ree; Biswas, Devanik; Wang, Justin; Shin, Yu; Loder, Alexis; Karuppagounder, Senthilkumar S; Wrann, Christiane D; Dawson, Valina L; Spiegelman, Bruce M; Dawson, Ted M 2022. Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin. Proceedings of the National Academy of Sciences of the United States of America, 119 36, e2204835119

Navarrete-Perea, Jose; Guerra-Moreno, Angel; Van Vranken, Jonathan; Isasa, Marta; Paulo, Joao A; Gygi, Steven P 2021. Iron Deficiency and Recovery in Yeast: A Quantitative Proteomics Approach. Journal of proteome research, 20 5, 2751-2761

Van Vranken, Jonathan G; Li, Jiaming; Mitchell, Dylan C; Navarrete-Perea, José; Gygi, Steven P 2021. Assessing target engagement using proteome-wide solvent shift assays. eLife, 10 ,

Li, Jiaming; Van Vranken, Jonathan G; Paulo, Joao A; Huttlin, Edward L; Gygi, Steven P 2020. Selection of Heating Temperatures Improves the Sensitivity of the Proteome Integral Solubility Alteration Assay. Journal of proteome research, 19 5, 2159-2166

Li, Jiaming; Van Vranken, Jonathan G; Pontano Vaites, Laura; Schweppe, Devin K; Huttlin, Edward L; Etienne, Chris; Nandhikonda, Premchendar; Viner, Rosa; Robitaille, Aaron M; Thompson, Andrew H; Kuhn, Karsten; Pike, Ian; Bomgarden, Ryan D; Rogers, John C; Gygi, Steven P; Paulo, Joao A 2020. TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples. Nature methods, 17 4, 399-404

Nowinski, Sara M; Van Vranken, Jonathan G; Dove, Katja K; Rutter, Jared 2018. Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis. Current biology : CB, 28 20, R1212-R1219

Van Vranken, Jonathan G; Nowinski, Sara M; Clowers, Katie J; Jeong, Mi-Young; Ouyang, Yeyun; Berg, Jordan A; Gygi, Jeremy P; Gygi, Steven P; Winge, Dennis R; Rutter, Jared 2018. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Molecular cell, 71 4, 567-580.e4

Zurita Rendón, Olga; Fredrickson, Eric K; Howard, Conor J; Van Vranken, Jonathan; Fogarty, Sarah; Tolley, Neal D; Kalia, Raghav; Osuna, Beatriz A; Shen, Peter S; Hill, Christopher P; Frost, Adam; Rutter, Jared 2018. Vms1p is a release factor for the ribosome-associated quality control complex. Nature communications, 9 1, 2197

Cory, Seth A; Van Vranken, Jonathan G; Brignole, Edward J; Patra, Shachin; Winge, Dennis R; Drennan, Catherine L; Rutter, Jared; Barondeau, David P 2017. Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Proceedings of the National Academy of Sciences of the United States of America, 114 27, E5325-E5334

Van Vranken, Jonathan G; Jeong, Mi-Young; Wei, Peng; Chen, Yu-Chan; Gygi, Steven P; Winge, Dennis R; Rutter, Jared 2016. The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis. eLife, 5 ,

Van Vranken, Jonathan G; Rutter, Jared 2016. The Whole (Cell) Is Less Than the Sum of Its Parts. Cell, 166 5, 1078-1079

Van Vranken, Jonathan G; Na, Un; Winge, Dennis R; Rutter, Jared 2015. Protein-mediated assembly of succinate dehydrogenase and its cofactors. Critical reviews in biochemistry and molecular biology, 50 2, 168-80

Van Vranken, Jonathan G; Rutter, Jared 2015. You Down With ETC? Yeah, You Know D! Cell, 162 3, 471-3

Schell, John C; Olson, Kristofor A; Jiang, Lei; Hawkins, Amy J; Van Vranken, Jonathan G; Xie, Jianxin; Egnatchik, Robert A; Earl, Espen G; DeBerardinis, Ralph J; Rutter, Jared 2014. A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Molecular cell, 56 3, 400-413

Van Vranken, Jonathan G; Bricker, Daniel K; Dephoure, Noah; Gygi, Steven P; Cox, James E; Thummel, Carl S; Rutter, Jared 2014. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell metabolism, 20 2, 241-52

Bricker, Daniel K; Taylor, Eric B; Schell, John C; Orsak, Thomas; Boutron, Audrey; Chen, Yu-Chan; Cox, James E; Cardon, Caleb M; Van Vranken, Jonathan G; Dephoure, Noah; Redin, Claire; Boudina, Sihem; Gygi, Steven P; Brivet, Michèle; Thummel, Carl S; Rutter, Jared 2012. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science (New York, N.Y.), 337 6090, 96-100